dna polymerase beta|Cellular Roles of DNA Polymerase Beta : Tagatay Mammalian DNA polymerase beta (beta-pol) is a single polypeptide chain enzyme of 39kDa. beta-pol has enzymatic activities appropriate for roles in base excision repair and other DNA metabolism events involving gap-filling DNA synthesis.
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dna polymerase beta,
DNA polymerase beta, also known as POLB, is an enzyme present in eukaryotes. In humans, it is encoded by the POLB gene. [4] In eukaryotic cells, DNA polymerase beta (POLB) performs base excision repair (BER) required for DNA maintenance, .
DNA polymerase (pol) β is a small eukaryotic DNA polymerase composed of two domains. Each domain contributes an enzymatic activity (DNA synthesis and deoxyribose phosphate lyase) during the repair of simple base lesions.DNA polymerase beta is the smallest among the eukaryotic DNA polymerases. It is typically described as a DNA repair enzyme, involved in various types of DNA repair such as Base Excision Repair (BER), Nucleotide Excision Repair (NER), post-replicative Mismatch Repair (MMR), and Double Strand Break Repair (DSBR) .
dna polymerase betaDNA polymerase beta is the smallest among the eukaryotic DNA polymerases. It is typically described as a DNA repair enzyme, involved in various types of DNA repair such as Base Excision Repair (BER), Nucleotide Excision Repair (NER), post-replicative Mismatch Repair (MMR), and Double Strand Break Repair (DSBR) .Pol ß is a key enzyme in the base excision repair (BER) pathway that functions in gap filling DNA synthesis subsequent to the excision of damaged DNA bases. A major focus of our studies is on the cellular roles of Pol ß.
DNA polymerase beta (beta-pol) is a single-copy gene that is considered to be part of the DNA repair machinery in mammalian cells. Using two human genomic libraries we have cloned the complete human beta-pol gene and determined the organization of the beta-pol coding sequence within the gene.
Cellular Roles of DNA Polymerase Beta Mammalian DNA polymerase beta (beta-pol) is a single polypeptide chain enzyme of 39kDa. beta-pol has enzymatic activities appropriate for roles in base excision repair and other DNA metabolism events involving gap-filling DNA synthesis.
DNA polymerase beta contributes two enzymatic activities: DNA synthesis and deoxyribose-phosphate removal through nucleotidyl transferase and lyase mechanisms, respectively.dna polymerase beta Cellular Roles of DNA Polymerase Beta Beverly A. Baptiste, Stephanie L. Baringer, Tomasz Kulikowicz, Joshua A. Sommers, Deborah L. Croteau, Robert M. Brosh, Vilhelm A. Bohr. DNA polymerase β outperforms DNA polymerase γ in key mitochondrial base excision repair activities.
dna polymerase beta|Cellular Roles of DNA Polymerase Beta
PH0 · The human DNA polymerase beta gene structure. Evidence of
PH1 · Structure and Mechanism of DNA Polymerase β
PH2 · DNA polymerase beta
PH3 · DNA Polymerase β
PH4 · DNA Polymerase Beta
PH5 · Cellular Roles of DNA Polymerase Beta
PH6 · Activities and mechanism of DNA polymerase beta